实验室负责人：邢维满 教授
邢维满，上海师范大学生命科学学院教授，博士生导师。2000年毕业于南开大学生命科学学院，获学士学位；2008年毕业于中国科学院生物物理研究所&北京生命科学研究所，获理学博士学位；之后在美国霍华德休斯医学研究所/华盛顿大学从事博士后研究。2014年加入中国科学院上海植物逆境生物学研究中心，任研究员。2015年入选国家海外高层次人才引进计划。2019年进入上海师范大学工作。迄今已在Nature，Nature communications, PNAS, Cell Res, Molecular plant 等国际著名刊物上发表学术论文多篇。
学术团队
教 授： 邢维满
讲 师： 蔡汝洁
研究方向：
1. 植物病原菌致病机制
2. 植物抗病机制
3. 生物活性小分子的感知机制
代表性论文：
1. Liu MX , Wang FF , He B , Hu JX, Dai Y, Chen WZ, Yi MX, Zhang HF, Ye YH, Cui ZL , Zheng XB, Wang P, Xing WM*, Zhang ZG* (2024) Targeting Magnaporthe oryzae effector MoErs1 and host papain-like protease OsRD21 interaction to combat rice blast. Nat Plants.
2. Guo BD, Hu QL, Yao DQ, Kong GH, Han CY, Dong SM, Liu FQ, Xing WM*, Wang YC* (2023) Structural analysis of Phytophthora sojae effector Avr3b reveals a novel WY-Nudix conformation. In submission
3. Zhou J, Hu Q, Xiao X, Yao D, Ge S, Ye J, Li H, Cai R, Liu R, Meng F, Wang C, Zhu JK, Lei M*, Xing W*. (2021) Mechanism of Phosphate Sensing and Signaling Revealed by Rice SPX1-PHR2 Complex Structure.Nat Commun. 12(1):7040.
4.Lin Y, Hu Q, Zhou J, Yin W, Yao D, Shao Y, Zhao Y, Guo B, Xia Y, Chen Q, Wang Y, Ye W, Xie Q, Tyler BM, Xing W*, Wang Y*. 2021. Phytophthora sojae effector Avr1d functions as an E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2018312118.
5.Li J, Xin J, Zhao X, Zhao Y, Wang T, Xing W*, Tao X*. 2021. Expression, purification and crystallization of the N-terminal Solanaceae domain of the Sw-5b NLR immune receptor. Acta Crystallogr F Struct Biol Commun. 77(Pt 1):8-12.
6. Wang F, Fang J, Guan K, Luo S, Dogra V, Li B, Ma D, Zhao X, Lee KP, Sun P, Xin J, Liu T, Xing W*, Kim C*. 2020. The Arabidopsis CRUMPLED LEAF protein, a homolog of the cyanobacterial bilin lyase, retains the bilin-binding pocket for a yet unknown function. Plant J. 104(4):964-978.
7. Lin L, Zhang C, Chen Y, Wang Y, Wang D, Liu X, Wang M, Mao J, Zhang J, Xing W, Liu L, Li J. 2019. PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex. 2019. Nat Commun. 10(1):3492.
8. Guo B, Wang H, Yang B, Jiang W, Jing M, Li H, Xia Y, Xu Y, Hu Q, Wang F, Yu F, Wang Y, Ye W, Dong S, Xing W*, Wang Y*. 2019. Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection. Mol Plant. 12(4):552-564.
9. Chen W, Gong P, Guo J, Li H, Li R, Xing W, Yang Z, Guan Y. 2018. Glycolysis regulates pollen tube polarity via Rho GTPase signaling. PLoS Genet. 14(4).
10. Rosas-Diaz T, Zhang D, Fan P, Wang L, Ding X, Jiang Y, Jimenez-Gongora T, Medina-Puche L, Zhao X, Feng Z, Zhang G, Liu X, Bejarano ER, Tan L, Zhang H, Zhu JK, Xing W, Faulkner C, Nagawa S, Lozano-Duran R. 2018. A virus-targeted plant receptor-like kinase promotes cell-to-cell spread of RNAi. Proc Natl Acad Sci U S A. 115(6):1388-1393.
11. Huang J, Gu L, Zhang Y, Yan T, Kong G, Kong L, Guo B, Qiu M, Wang Y, Jing M, Xing W, Ye W, Wu Z, Zhang Z, Zheng X, Gijzen M, Wang Y, Dong S. 2017. An oomycete plant pathogen reprograms host pre-mRNA splicing to subvert immunity. Nat Commun. 8(1):2051.
12. Nangle S, Xing W*, Zheng N*. 2013. Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Cell Res. 23(12):1417-1419.
13. Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, Zheng N. 2013. SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature. 496(7443):64-68.
14. Xing W, Zou Y, Liu Q, Liu J, Luo X, Huang Q, Chen S, Zhu L, Bi R, Hao Q, Wu JW, Zhou JM, Chai J. 2007. The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature. 449(7159):243-247.
15. Xiang T, Zong N, Zou Y, Wu Y, Zhang J, Xing W, Li Y, Tang X, Zhu L, Chai J, Zhou JM. 2008.Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol. 18(1):74-80.
16. Liu HL, Zhou HN, Xing WM, Zhao JF, Li SX, Huang JF, Bi RC. 2004. 2.6 A resolution crystal structure of the bacterioferritin from Azotobacter vinelandii. FEBS Lett. 573(1-3):93-98.